Mechanism of the effect

Free oxygen radicals - are very reactive particles with an unpaired electron, which due to its instability can disturb and destroy healthy cells and thereby slow down or even stop wound healing.

Healing is disturbed by free oxygen radicals which form everywhere where an injury occurs. During pathological healing, their production is higher, which further potentiates the ongoing inflammation, making healing and the formation of new tissue difficult. This vicious circle can be interrupted only by capturing the free radicals and thereby accelerating the overall period of wound healing, which goes hand in hand with cost-saving as well as providing patient comfort of course.

Binding radical oxygen species (ROS) during the inflammatory process in the tissue results in reactive oxygen radicals (ROS), which are released into the tissue. Enzymes are often activated in the damaged cells which create these radicals and hydrogen peroxide, which means that reactive oxygen products increase in the damaged tissue. The excessive concentration of ROS causes damage even of healthy cells resulting in the development of inflammatory reaction and slows down the formation of the new epithelium and wound healing. The negative effect of excessive production of ROS on the course of healing of the damage tissue is documented in medical literature since the early 1990s, just as the positive effect of substances restricting the action of ROS (e.g. SOD, antioxidants. The steric hindrance amino acid which is chemically built into the structure of HemaGel®, works as a highly effective scavenger of reactive oxygen products (ROS) and transforms it into stable compounds not harmful to the organism.

 

PREVENTNG ACCESS OF INFECTION TO THE WOUND

Due to the application of HemaGel to the wound, you will prevent the immediate access of infection to the wound. Apply HemaGel in a thin 1-2 mm layer to the wound slightly overlapping into the healthy skin. This will form a barrier against infection from the area around the wound.

 

Method of moist wound is nothing new. The ancient Sumerians, Egyptians, Greeks and Romans used honey as the basic ingredient for healing balms. Its application to wounds helped (apart from other effects) to maintain a moist environment. Many years later dry sterile gauze replaced the established procedures. This was marked for its good absorbing abilities greatly desiccating the wound. For a long time it was the only dressing material used.

In the 1960s it was shown that a wound which heals in a moist environment has a 40 percent shorter healing time as compared to a covered dry dressing. New materials began being developed. Despite this, it took almost 30 years before moist healing was introduced in broad medical practice.
Moist healing supports the stage of granulation and epithelialization in the wound. Besides this, the HemaGel type of moist cover can maintain the right pH and constant temperature in the wound. A very important benefit to the patient is that thanks to the application of moist healing, the dressings are less painful and less frequent.
Thanks to all these facts patient treatment is less expensive.

EFFECT OF HEMAGEL IN INDIVIDUAL STAGES OF HEALING

The fundamental difference compared to other available products is that the EFFECTS OF HEMAGEL DO NOT DEPEND ON THE AMOUNT OF ABSORBED ACTIVE SUBSTANCE. The accelerated healing of HemaGel is due solely to its chemical structure, which immediately after application establishes IDEAL CONDITIONS in the wound….

More information: The accelerated healing THEREFORE IS NOT CAUSED BY THE SUPPLEMENTATION OF THE ACTIVE SUBSTANCES IN THE WOUND, but the ELIMINATION OF THE FACTORS, WHICH COMPLICATE WOUND HEALING (ideal environment, infection, ROS). Hence the perfect reparation processes of the organism take place without external influences and therefore more quickly.

What is characteristic for HemaGel is that IT DOES NOT GET ABSORBED, BUT REMAINS FLEXIBLE ON THE WOUND and moves around the area of the healthy skin.

The fact that HemaGel remains on the surface and IS NOT RELEASED FROM ITS WATER STRUCTURE, even during LONG-TERM APPLICATION , means IT DOES NOT CAUSE WOUND MACERATION.

Exudation stage

Immediately after application the ROS are eliminated – thereby potentiating the effect of HemaGel and thereby accelerating healing as compared to standard products. HemaGel absorbs secretions from the wound, both substances mix together slightly. The growth factors remain in the wound. In the case of necrosis HemaGel acts by removing the necrotic tissue. It adds moisture to the wound, prevents the formation of scabs, crusts and cracking of a desiccated wound. HemaGel remains in the wound and protects it against the infection from the surrounding area.

Granulation stage

Supports the growth and formation of granulated tissue. Prevents hyper-granulation. In deep defects it supports granulation from the bottom of the wound and prevents its premature closure.

Epithelization stage

Supports the division of skin cells and their growth over the edges of the wound. Softens and macerates new tissue, prevents the compression of scarred tissue and the constriction of the surrounding skin. DOES NOT MACERATE the edges of the wound.

 

The negative effects of ROS in the process of wound healing are shown by the following papers:

1. Oxidative stress in normal and impaired wound repair
Matthias Schäfer, Sabine Werner
Zdroj: Pharmacological Research, Volume 58, Issue 2, August 2008, Pages 165–171 DOI: 10.1016/j.phrs.2008.06.004
WWW: http://www.sciencedirect.com/science/article/pii/S1043661808001072


2. Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products
S.D. Fitzmaurice, R.K. Sivamani, R.R. Isseroff
Zdroj: Skin Pharmacology and Physiology 2011;24:113–126.
DOI: 10.1159/000322643
WWW: http://www.karger.com/Article/FullText/322643


3. Reactive oxygen species (ROS) – a family of fate deciding molecules pivotal in constructive inflammation and wound healing
N Bryan, H Ahswin, N Smart, Y Bayon, S Wohlert, JA Hunt
Zdroj: European Cells and Materials 2012;24:249-65.
DOI: N/A
WWW: http://www.ecmjournal.org/journal/papers/vol024/vol024a18.php


4. Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: A PRCT
Sandra C. Blass, Hans Goost, René H. Tolba, Birgit Stoffel-Wagner, Koroush Kabir, Christof Burger, Peter Stehle, Sabine Ellinger
Zdroj: Clinical Nutrition, Volume 31, Issue 4 , Pages 469-475, August 2012.
DOI: 10.1016/j.clnu.2012.01.002
WWW: http://www.clinicalnutritionjournal.com/article/S0261-5614(12)00004-0/abstract


5. Topical treatment with anti-oxidants and Au nanoparticles promote healing of diabetic wound through receptor for advance glycation end-products
Siang-An Chen, Han-Min Chen, Yeong-Der Yao, Chi-Feng Hung, Chi-Shun Tu, Yao-Jen Liang
Zdroj: European Journal of Pharmaceutical Sciences, Volume 47, Issue 5, 18 December 2012, Pages 875–883
DOI: 10.1016/j.ejps.2012.08.018